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Acta Bioqum Cln Latinoam

Zhonghua Nei Ke Za Zhi 56 (12), 924929

Dysbiosis Altered microbial metabolism may increase endotoxin and other compounds delivered directly to the liver through the portal vein

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In this Review, we discuss the progress made in the development of such modulators for the treatment of depression, and examine recent preclinical and translational studies that have investigated the mechanisms of action of glutamate-targeting antidepressants

Additionally, fluorene altered hepatic expression of genes involved in glucose and glycogen metabolism (increased gluconeogenic Pck1 , decreased Gck expression) in CD-fed mice although this group exhibited lower fasting glucose levels and reduced hepatic glycogen storage, further implicating fluorenes disruption of glucose metabolism